“ZAMONAVIY TIBBIYOTDA PSEVDOALLERGIYA: AHOLI ORASIDA ORTIB BORAYOTGAN GLOBAL MUAMMO”
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Abstract
Mazkur maqolada psevdoallergiyaning klinik, patogenetik va molekulyar asoslari tahlil qilinadi. Psevdoallergiya — bu immunoglobulin E (IgE) ishtirokisiz kechuvchi, ammo haqiqiy allergik reaksiyalarga klinik jihatdan o‘xshash holat bo‘lib, asosan mastotsitlar va bazofillarning bevosita stimulyatsiyasi natijasida rivojlanadi. Maqolada psevdoallergiyaning asosiy mexanizmlari — mastotsitlarning degranulyatsiyasi, mediatorlar (histamin, serotonin, triptaza) ajralishi, hamda ularning organizm tizimlariga ta’siri batafsil yoritilgan. Shuningdek, haqiqiy allergiya bilan farqlovchi biomarkerlar, psevdoallergiyani aniqlashda eksperimental yondashuvlar (provokatsion testlar, mediator darajasini o‘lchash, mastotsit inhibisiyasini baholash) va ularning diagnostik ahamiyati muhokama qilinadi. Ushbu ish psevdoallergiyaning klinik va laborator belgilarini aniqlashtirish, hamda yangi terapevtik strategiyalar ishlab chiqish uchun ilmiy asos yaratadi.
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References
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