GENERAL ANALYSIS OF FUROSEMIDE-CONTAINING PREPARATIONS BY PHYSIC-CHEMICAL METHODS
Keywords:
drug, sodium hydroxide, alcoholAbstract
Increased bioavailability and rapid onset of the diuretic effect of furosemide are necessary for accelerated elimination of toxins in acute and chronic diseases associated with swelling, as well as in acute and chronic poisoning. In conditions where oral or parenteral administration of furosemide is difficult or impossible due to limitations in a number of diseases, it is important to use topical forms of furosemide, in particular, tablets for resorption. Experimental substantiation of quality standards and methods of analysis of tablets for resorption containing furosemide.
References
1. Smirnov I.V., Bryukhanov V.M., Bondarev A.A. and others. On the role of the carboxyl group in the furosemide molecule // Psychopharmacology and biological narcology. - 2007. - Vol. 7, Part 2. - Pp. 1952-1953.
2. Solomonov B.N., Sedov I.A. Methods for calculating the Gibbs energy of the hydrophobic effect and the specific interaction of nonelectrolytes in aqueous solutions // Journal of Physical Chemistry. - 2008. - Vol. 83, No. 7. - pp. 1259-1263.
3. Postnikov P.S., Bondarev A.A., Smirnov I.V. and others. Investigation of the effect of modification of the amino group of furosemide on diuretic activity using experimental and theoretical methods // Creation of new drugs : conference proceedings / ed. by E.D. Goldberg. Tomsk : Publishing House Vol. University, 2007, pp. 76-78.
